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Integrating these natural substances into wound care formulations—such as gels, ointments, and hydrogel dressings—has shown encouraging outcomes in both preclinical and clinical environments [111,112]

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Moreover, the activity of γ-glutamylcysteine synthetase (γ-ECS), which catalyses the first step of the committed GSH synthesis pathway, is regulated by oxidation, both at the level of oxidant-induced de-repression of γ-ECS translation and at the post-translational level by oxidation of enzyme thiol groups (Hicks et al ., 2007